Inhibitors of cell-cycle
In recent years we have witnessed a considerable progress in our understanding of the cell cycle and especially the factors that regulate it, both in normal cell and in the tumor. In particular, many pre-clinical data not only confirmed the importance of substances called cyclines and cycline-dependent kinases in the control processes of normal cell replication, but also and above all, have clarified many points about the relationship between the dark disruption of these processes and cancer progression. This knowledge has consequently resulted in a strong impetus for the development of cycline-dependent kinase inhibitors as anti-neoplastic agents (e.g. flavopiridolo, staurosporine, paulloni …). The use of these drugs is still very experimental.